Health Report Final - Flipbook - Page 51
Coefficient Of Inbreeding (COI)
The degree of inbreeding can be measured using a calcula on called the coefficient of in‐
breeding (COI).
This calculates the probability that two copies of a gene have been inherited from an an‐
cestor common to both the mother and the father. The lower the degree of inbreeding, the
lower the inbreeding coefficient.
To put the COI results into perspec ve:
0%
=
a dog with two apparently unrelated parents (based on all available
pedigree informa on)
12.5% =
the gene c equivalent of a dog produced from a grandfather to grand
daughter ma ng, or the ma ng of a half-brother/sister
25%
the gene c equivalent of a dog produced from a father to daughter ma ng,
or the ma ng of full brother/sister
=
More than 25% -inbreeding is accumula ve, so if it has occurred to a significant degree
over several genera ons, the inbreeding coefficient may exceed 25%.
(NB: The bo om numbers on the graph indicate the number assigned to the dog to keep
their data anonymous)
AVERAGE
KENNEL CLUB COI
GENETIC COI (WCSS Embark project)
18.3
39.8
Following the Embark project data analysis it became apparent as shown above in the
image that the Kennel club COI and Gene c COI were vastly different for the dogs
par cipa ng. The KC COI has been placed lowest to highest to illustrate how a low KC COI
of a pairing does not result in a low gene c COI at all.
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